Precocious Puberty

Precocious Puberty

Definition 

Pubertal change in boys before 9 years and in girls before 8 years is termed precocious puberty.

• It is more common in girls 
• There is a greater chance of finding an organic cause in boys.

Etiology 

1. Idiopathic 

2. CNS disorders 

• Tumors 
• Congenital anomalies 
• Post-inflammatory
• Trauma 

3. Syndromes

• McCune Albright
• Neurofibromatosis
• Tuberous Sclerosis 
• Russell-silver

4. Gonadal Tumors 

• Ovarian
• Granulosa-theca cell tumor 
• Granulosa-luteal cell cysts 

Testicular

• Leydig cell tumors 
• Adrenal rest tumors 
• Adrenal disorders 
• Cong. Adrenal Hyperplasia (boys)
• Adenomas & Carcinomas 
• (Virilizing - boys)
• (Feminizing - girls)

5. Exogenous sex steroids 

• Gonadotropin secreting tumors 
• Chorioepithelioma
• Teratoma
• Hepatoblastoma (boys)

6. Primary hypothyroidism

• Incomplete sexual precocity
• Premature thelarche
• Premature adrenarche